The RNF7 Rabbit pAb Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to RNF7. This antibody recognizes Human, Mouse, and Rat antigen. The RNF7 Rabbit pAb Antibody has been shown to work in the following applications: Immunofluorescence, and Western Blot.
Description
Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:10851089). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents