MyBioSource.com's Integrin beta 4 Antibody is a Rabbit monoclonal antibody. The Integrin beta 4 Antibody was generated using ITGB4 as the antigen. It reacts with Human, and Mouse. This antibody has been shown to work in applications such as: Immunohistochemistry, and Western Blot.
Description
Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, collagen and vitronectin. Certain integrins can also bind to soluble ligands, such as fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Integrin beta 4 (ITGB4), also known as CD104, is a 1, 822 amino acid single-pass type I membrane protein belonging to the Integrin beta chain family. Known to associate with Integrin alpha6, Integrin beta 4 functions as a receptor for Laminin and is predominantly expressed by epithelia. Integrin beta 4 exists as five alternatively spliced isoforms that are encoded by a gene located on human chromosome 17q25.1