MyBioSource.com's Rabbit Anti-Topoisomerase II alpha Antibody is a Rabbit monoclonal antibody. The Rabbit Anti-Topoisomerase II alpha Antibody was generated using TOP2A as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
The topoisomerase II-alpha isoform is a 170kDa nuclear protein and plays an important role in DNA synthesis and RNA transcription, as well as chromosomal segregation during mitosis. Topoisomerase II-alpha is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells, and has been shown to be over-expressed in many human cancers. Decreased expression of Topoisomerase II-alpha is the predominant mechanism of resistance to several chemotherapeutic agents