The Rabbit Anti-TNFSF14 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to TNFSF14. This antibody recognizes Human antigen. The Rabbit Anti-TNFSF14 Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
Rabbit anti Human TNFSF14 antibody, recognizes TNFSF14 also known as LIGHT, Herpes virus entry mediator and CD258. TNFSF14 is the ligand of the receptor TNFRSF14, which is the cell surface receptor that the Herpes virus uses to attach to the cell surface and to enter into the cell, it is also a ligand of lymphotoxin-beta receptor (Ware & Sedy 2011). Signaling events initiated upon binding of TNFSF14 to these receptors is cell dependent. However, the responses are often related to immune system stimulation including the production of various cytokines, adhesion molecules that control the migration and positioning of dendritic cells and lymphocytes (Skeate et al. 2020, Tang et al. 2016).
TNFSF14 is primarily expressed by activated T cells, activated natural killer cells and immature dentritic cells. It is initially synthesized as a type II transmembrane protein, which can be proteolytically cleaved to release a soluble bioactive form (Ware & Sedy 2011)