MyBioSource.com's Rabbit Anti-Estrogen Related alpha Antibody is a Rabbit monoclonal antibody. The Rabbit Anti-Estrogen Related alpha Antibody was generated using ESRRA, and Estrogen Related Receptor alpha as the antigen. It reacts with Human, Mouse, and Rat. This antibody has been shown to work in applications such as: Other.
Description
Estrogen related receptor alpha (ERRalpha) is a nuclear receptor in the superfamily of ligand-regulated transcription factors and is a member of the NR3B orphan nuclear receptor subgroup (consisting of alpha, beta and gamma). ERRalpha plays a role in modulating the estrogen signaling pathway. In addition, the expression of ERRalpha has been shown to increase during fasting and cold exposure. ERRalpha may be important for regulating mitochondrial biogenesis and oxidative metabolism by acting directly on genes necessary for mitochondrial function. Mice lacking ERRalpha are unable to maintain their body temperature in the cold. ERRalpha may also be involved in the maintenance and formation of cartilage. This information could be useful in finding therapeutic agents for a variety of diseases affecting the joints