MyBioSource.com's TGF alpha Conjugated Antibody is a Rabbit monoclonal antibody. The TGF alpha Conjugated Antibody was generated using TGFA as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Other.
Description
Transforming growth factor-alpha (TGFalpha) is an acid- and heat-stable 50 amino acid protein originally found in rodents and humans. TGFalpha is 33% homologous at the amino acid level to epidermal growth factor (EGF). TGFalpha binds to the EGF receptor, mediates tyrosine phosphorylation of the receptor and promotes anchorage-independent growth of normal rat fibroblasts in soft agar in the presence of transforming growth factor-beta. TGFalpha is secreted by a variety of transformed cells and tumors, embryonic cells and some normal adult cells. TGFalpha bioactivity has been found in the urine of cancer patients. It has been suggested that it may act as an autocrine growth factor for the induction or maintenance of malignancy