The Collagen XVII Rabbit pAb Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to COL17A1. This antibody recognizes Human antigen. The Collagen XVII Rabbit pAb Antibody has been shown to work in the following applications: Immunocytochemistry, Immunofluorescence, and Immunohistochemistry.
Description
May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. The 120kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies.MiscellaneousBoth the 120kDa linear IgA disease antigen and the 97kDa linear IgA disease antigen of COL17A1, represent major antigenic targets of autoantibodies in patients with linear IgA disease (LAD). LAD is a subepidermal blistering disorder characterized by tissue-bound and circulating IgA autoantibodies to the dermal-epidermal junction. These IgA autoantibodies preferentially react with 97 and the 120kDa forms, but not with the full-length COL17A1, suggesting that the cleavage of the ectodomain generates novel autoantigenic epitopes