The AMACR Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to alpha-methylacyl-CoA racemase, and AMACR. This antibody recognizes Mouse, and Rat antigen. The AMACR Polyclonal Antibody has been shown to work in the following applications: Immunohistochemistry, and Western Blot.
Description
AMACR(Alpha-methylacyl-CoA racemase) belongs to the CaiB/BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer (PCa). However, AMACR expression is down-regulated at the transcript and protein level in hormone-refractory metastatic PCa, suggesting a hormone-dependent expression of AMACR. It has 3 isoforms produced by alternative splicing. Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency (AMACRD) and congenital bile acid synthesis defect type 4 (CBAS4)