MyBioSource.com's Glutathione Reductase Rabbit mAb is a Rabbit monoclonal antibody. The Glutathione Reductase Rabbit mAb Antibody was generated using GSR as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, and Western Blot.
Description
This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010]
Maintains high levels of reduced glutathione in the cytosol.MiscellaneousThe active site is a redox-active disulfide bond