The CRACR2A Rabbit pAb Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to CRACr2A. This antibody recognizes Mouse antigen. The CRACR2A Rabbit pAb Antibody has been shown to work in the following applications: Western Blot.
Description
Ca2+-binding protein that plays a key role in store-operated Ca2+ entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+ concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca2+ resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex