MyBioSource.com's BRAT1 Rabbit mAb is a Rabbit monoclonal antibody. The BRAT1 Rabbit mAb Antibody was generated using BRAT1 as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Flow Cytometry, Immunoprecipitation, and Western Blot.
Description
Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress (PubMed:16452482, PubMed:22977523). Plays a role in regulating mitochondrial function and cell proliferation (PubMed:25070371). Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors (PubMed:25657994)