The DKK3 (N-Term) Rabbit pAb Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to DKK3. This antibody recognizes Human, and Mouse antigen. The DKK3 (N-Term) Rabbit pAb Antibody has been shown to work in the following applications: Western Blot.
Description
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity)