MyBioSource.com's Lipoamide Dehydrogenase Rabbit pAb is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Western Blot. The Lipoamide Dehydrogenase Rabbit pAb Antibody was generated using DLD as the antigen and it reacts with Human, Mouse, and Rat.
Description
Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex) (PubMed: 15712224, PubMed: 16442803, PubMed: 16770810, PubMed: 17404228, PubMed: 20160912, PubMed: 20385101). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed: 29211711). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed: 29211711). In monomeric form may have additional moonlighting function as serine protease (PubMed: 17404228). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction