The Rabbit Anti-alpha Synuclein Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to PAK2. This antibody recognizes Human, Mouse, and Rat antigen. The Rabbit Anti-alpha Synuclein Antibody has been shown to work in the following applications: Other.
Description
Three recently identified isoforms of serine/threonine kinases, designated alpha PAK p68, beta PAK p65 and gamma PAK p62, have been shown to exhibit a high degree of sequence homology with the S. cerevisiae kinase STE20, involved in pheromone signaling. The alpha, beta, and gamma PAK isoforms complex specifically with Rac1 and Cdc42 in their active GTP bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation. Once phosphorylated and their affinity for Rac/Cdc42 reduced, the PAK isoforms disassociate from the complex to seek downstream substrates. One such putative substrate is MEK kinase, an upstream effector of MEK4 which is involved in the JNK signaling pathway. While the PAK isoforms interact in a GTP-dependent manner with Rac1 and Cdc42, they do not interact with Rho