The Phospho-Cdc6 (Ser106) Rabbit mAb Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to Cdc6. This antibody recognizes Human antigen. The Phospho-Cdc6 (Ser106) Rabbit mAb Antibody has been shown to work in the following applications: Western Blot.
Description
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]
Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.RegionsFeature keyPosition(s)Description