MyBioSource.com's UTF1 Antibody is a Mouse monoclonal antibody. The UTF1 Antibody was generated using UTF1 as the antigen. It reacts with Human, Mouse, and Rat. This antibody has been shown to work in applications such as: Immunocytochemistry, and Western Blot.
Description
Undifferentiated embryonic cell transcription factor 1 is a protein in humans that is encoded by the UTF1 gene. UTF1, first reported in 1998, is expressed in pluripotent cells including embryonic stem cells and embryonic carcinoma cells. Its expression is rapidly reduced upon differentiation. UTF1 protein is localized to the cell nucleus, where it functions to regulate the pluripotent chromatin state and buffer mRNA levels by promoting degradation of mRNA. Aberrant expression of UTF1 has also been reported in cervical cancer cells, where the UTF1 gene promoter loses methylation and becomes abnormally expressed compared to normal cervical cells