The Rabbit Anti-beta-Catenin Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to catenin beta 1, and CTNNB1. This antibody recognizes Human, Mouse, and Rat antigen. The Rabbit Anti-beta-Catenin Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, Immunocytochemistry, and Western Blot.
Description
beta-Catenin is a 92kDa protein that binds to the cytoplasmic tail of E-Cadherin. The cadherins, transmembrane adhesion molecules, are found with catenins at adherens junctions. Deletions in the cytoplasmic domain of E-Cadherin eliminate catenin binding and result in a loss of cell adhesion. Tyrosine phosphorylation of beta-Catenin can regulate its interaction with critical components of adherens junctions. Both Fer and Fyn Kinases phosphorylate tyrosine 142 in vitro. Overexpression of these kinases in epithelial cells disrupts interactions between alpha- and beta-Catenins. The phosphorylation of tyrosine 142 may act as a switch from the transcriptional to the adhesive role of beta-Catenin. Src family kinases can also phosphorylate tyrosine 86, 489, and 654 in beta-Catenin. Tyr-654 phosphorylation regulates beta-Catenin binding to E-cadherin, while c-Abl phosphorylation of Tyr-489 decreases beta-Catenin binding to N-Cadherin and leads to nuclear translocation and transcriptional activation