The ATG4A Rabbit pAb Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to ATG4A. This antibody recognizes Human, Mouse, and Rat antigen. The ATG4A Rabbit pAb Antibody has been shown to work in the following applications: Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
The cysteine protease Atg4 is pivotal to autophagosome membrane generation and regulation. Atg4 primes the Atg8 homologue for lipidation by cleaving its carboxy terminus and exposing its glycine residue for E1-like enzyme Atg7. The Atg8 homologue is transferred to the E2-like enzyme Atg3 before forming the Atg8-PE conjugate. During later stages of autophagy, Atg4 can reverse this lipidation event by cleaving PE, thereby recycling the Atg8 homologue