The RGS14 Conjugated Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to RGS14. This antibody recognizes Human, and Mouse antigen. The RGS14 Conjugated Antibody has been shown to work in the following applications: Other.
Description
Acts as a regulator of G protein signaling (RGS). Modulates G protein alpha subunits nucleotide exchange and hydrolysis activities by functioning either as a GTPase-activating protein (GAP), thereby driving G protein alpha subunits into their inactive GDP-bound form, or as a GDP-dissociation inhibitor (GDI). Confers GDI activity on G (i) alpha subunits GNAI1 and GNAI3, but not G (o) alpha subunit GNAO1 and G (i) alpha subunit GNAI2. Confers GAP activity on G (o) alpha subunit GNAI0 and G (i) alpha subunits GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G (i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G (i)-alpha-dependent mechanism. Plays a role in cell division. Probably required for the nerve growth factor (NGF)-mediated neurite outgrowth. May be involved in visual memory processing capacity and hippocampal-based learning and memory