The Rabbit Anti-COP1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to COP1, and COP1 E3 ubiquitin ligase. This antibody recognizes Human, and Mouse antigen. The Rabbit Anti-COP1 Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1