The IFN alpha R1 Antibody from MyBioSource.com is a Mouse Monoclonal antibody to IFNAR1. This antibody recognizes Mouse antigen. The IFN alpha R1 Antibody has been shown to work in the following applications: Flow Cytometry, Immunoprecipitation, and Western Blot.
Description
The type I interferons (IFNs), and, are a group of structurally and functionally related proteins that are induced by either viruses or double stranded RNA and defined by their ability to confer an antiviral state in cells. The and IFNs appear to compete with one another for binding to a common cell surface receptor, while immune IFN (IFN) binds to a distinct receptor. The latter protein, IFN-R, is only weakly responsive to type I interferons in contrast to IFN-/R, which binds to and responds effectively to IFN- and to several of the IFN- subtypes. Moreover, IFN-/R is physically associated with the cytoplasmic tyrosine kinase JAK1 and thus, in addition to ligand binding, appears to be functionally involved in signal transduction. IFN-R1 is a receptor for IFN-/ and is present as the full chain (IFN-R1a) and as a splice-variant (IFN-R1). The IFN- receptor complex consists of an alpha subunit (IFN-R) and a beta subunit that is 332 amino acids in length (mouse) and 337 amino acids in length (human)