The Rabbit Anti-MDM4 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to MDM4, and MDM4 regulator of p53. This antibody recognizes Human antigen. The Rabbit Anti-MDM4 Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2. Two transcript variants, one protein-coding and the other likely not to be protein-coding, have been found for this gene