MyBioSource.com's Anti-CSK Purified is a Mouse monoclonal antibody. The Anti-CSK Purified Antibody was generated using Csk as the antigen. It reacts with Human, and Mouse. This antibody has been shown to work in applications such as: Immunocytochemistry, Immunoprecipitation, and Western Blot.
Description
C-terminal Src kinase (Csk) is a non-receptor protein tyrosine kinase which resembles Src-family kinases, but unlike them lacks the conserved autophosphorylation site, the regulatory C-terminal tyrosine as well as myristylation and palmitylation. Csk negatively regulates Src-family kinases by phosphorylation of their C-terminal regulatory tyrosine. Disruption of the csk gene causes constitutive activation of Src-family kinases, and overexpression of Csk usually counteracts their signaling. The Csk-mediated regulation of those Src-family kinases that are localized in lipid rafts is enabled by a ubiquitously expressed transmembrane adaptor PAG (also known as Cbp, Csk-binding protein), which recruits Csk