MyBioSource.com's Superoxide Dismutase 1 Rabbit mAb is a Rabbit monoclonal antibody. The Superoxide Dismutase 1 Rabbit mAb Antibody was generated using SOD1, and Superoxide Dismutase 1 as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Western Blot.
Description
The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.MiscellaneousThe protein (both wild-type and ALS1 variants) has a tendency to form fibrillar aggregates in the absence of the intramolecular disulfide bond or of bound zinc ions. These aggregates may have cytotoxic effects. Zinc binding promotes dimerization and stabilizes the native form