The PRAME Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to PRAME, and PRAME nuclear receptor transcriptional regulator. This antibody recognizes Human, Mouse, and Rat antigen. The PRAME Polyclonal Antibody has been shown to work in the following applications: Western Blot.
Description
This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants