The Phospho-Smad2 (Ser255) Rabbit mAb Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to SMAD2. This antibody recognizes Human, Mouse, and Rat antigen. The Phospho-Smad2 (Ser255) Rabbit mAb Antibody has been shown to work in the following applications: Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator