The Growth hormone receptor Rabbit mAb Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to GHR, and growth hormone receptor. This antibody recognizes Human, Mouse, and Rat antigen. The Growth hormone receptor Rabbit mAb Antibody has been shown to work in the following applications: Flow Cytometry, Immunoprecipitation, and Western Blot.
Description
This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway