The Rabbit Anti-MISRII AMHR2 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to AMHR2. This antibody recognizes Human, Mouse, and Rat antigen. The Rabbit Anti-MISRII AMHR2 Antibody has been shown to work in the following applications: Immunofluorescence.
Description
MISR II is a 573 amino acid protein encoded by the human gene AMHR2. MISR II belongs to the protein kinase superfamily, TKL Ser Thr protein kinase family, TGFB receptor subfamily and contains one protein kinase domain. Upon ligand binding, MISR II forms a receptor complex consisting of two type II and two type I transmembrane serine threonine kinases. These type II receptors rylate and activate type I receptors which autophosphorylate, then bind and activate Smad transcriptional regulators. MISR II also acts as a receptor for anti-Muellerian hormone. Defects in AMHR2 are the cause of persistent Muellerian duct syndrome type 2 (PMDS-2). PMDS-2 is a form of male pseudo-hermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males