The Vinculin Rabbit mAb Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to VCL, and Vinculin. This antibody recognizes Human, Mouse, and Rat antigen. The Vinculin Rabbit mAb Antibody has been shown to work in the following applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, and Western Blot.
Description
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion