The Rabbit Anti-Flt3 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to FLT3, and fms related receptor tyrosine kinase 3. This antibody recognizes Human, Mouse, and Non-Human Primate antigen. The Rabbit Anti-Flt3 Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
fms related tyrosine kinase 3 (FLT3), Homo sapiens. This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]