Anti-MAST4 antibody from GeneTex

Yes, the Anti-MAST4 antibody has been utilized in research to elucidate the role of MAST4 in neuroprotection, particularly in the context of the cellular response to 27-hydroxycholesterol. In a study, MAST4 was shown to be regulated by the amyloid precursor protein's intracellular domain, which promotes its abundance and kinase activity, contributing to cell survival mechanisms in neurodegenerative contexts (Gongol et al., 2017).

The Anti-MAST4 antibody has been validated for use in several applications, including Western Blotting, Immunocytochemistry, Immunofluorescence, Immunohistochemistry on paraffin-embedded sections, and Immunoprecipitation. This versatility allows researchers to explore MAST4's function across different experimental setups.

Yes, the Anti-MAST4 antibody is effective for detecting MAST4 in human samples, as it has been shown to recognize human MAST4 in various applications. This is particularly relevant for studies investigating MAST4's role in human diseases, such as Alzheimer's Disease, where its expression and activity may be altered.

The Anti-MAST4 antibody is reactive with multiple species, including human, mouse, and non-human primate samples. This broad reactivity makes it suitable for comparative studies across different model organisms in cell biology research.