MyBioSource.com's HOPX/HOD Rabbit mAb is a Rabbit monoclonal antibody. The HOPX/HOD Rabbit mAb Antibody was generated using HOPX as the antigen. It reacts with Mouse, and Rat. This antibody has been shown to work in applications such as: Immunoprecipitation, and Western Blot.
Description
Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (PubMed:12297045, PubMed:12297046). Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding