The Phospho-p53 (T55) Rabbit pAb Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to TP53, and tumor protein p53. This antibody recognizes Human antigen. The Phospho-p53 (T55) Rabbit pAb Antibody has been shown to work in the following applications: Western Blot.
Description
Plays an essential role in the regulation of cell cycle, specifically in the transition from G0 to G1. It is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing DNA-binding, oligomerization and transcription activation domains. It is postulated to bind as a tetramer to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor