MyBioSource.com's Granzyme B Rabbit pAb is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Immunoprecipitation. The Granzyme B Rabbit pAb Antibody was generated using Granzyme B, and GZMB as the antigen and it reacts with Human.
Description
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3,-7,-9 and 10 to give rise to active enzymes mediating apoptosis