The Caspase-1 Rabbit pAb Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to CASP1, and Caspase 1. This antibody recognizes Human, Mouse, and Rat antigen. The Caspase-1 Rabbit pAb Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, Immunohistochemistry, and Western Blot.
Description
Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive