MyBioSource.com's ATP6V0D1 Rabbit pAb is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The ATP6V0D1 Rabbit pAb Antibody was generated using ATP6V0D1 as the antigen and it reacts with Human, Mouse, and Rat.
Description
Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe2+ prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633)