The ITCH Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to ITCH. This antibody recognizes Human antigen. The ITCH Polyclonal Antibody has been shown to work in the following applications: Western Blot.
Description
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene