MyBioSource.com's RNF126 Conjugated Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Other. The RNF126 Conjugated Antibody was generated using RAD50 as the antigen and it reacts with Human.
Description
The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. RNF126 interacts with p21 and RNF126 over-expression increased p21 protein ubiquitination in an E3 ligase activity-dependent manner. RNF126 knockdown induced loss of cell viability in MDA-MB-231 and PC-3 can be partially rescued by depletion of p21. RNF126 stable knockdown in PC3 inhibited tumor growth in SCID mice