The DDX4 Rabbit pAb Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to DDX4, and DEAD-box helicase 4. This antibody recognizes Human, Mouse, and Rat antigen. The DDX4 Rabbit pAb Antibody has been shown to work in the following applications: Western Blot.
Description
ATP-dependent RNA helicase required during spermatogenesis (PubMed:10920202, PubMed:21034600). Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle. Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs