MyBioSource.com's uPA Receptor/U-PAR Rabbit pAb is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: EIA, Immunoassay, ELISA, Immunohistochemistry, and Western Blot. The uPA Receptor/U-PAR Rabbit pAb Antibody was generated using PLAUR as the antigen and it reacts with Human.
Description
This gene encodes the receptor for urokinase plasminogen activator and,given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of theextracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activatorand permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosylphosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several posttranslational cleavage reactions that have not yet been fully defined.
Function:Acts as a receptor for urokinase plasminogen activator.Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of UPA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form