MyBioSource.com's SUMO-2/3 Rabbit pAb is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Western Blot. The SUMO-2/3 Rabbit pAb Antibody was generated using small ubiquitin like modifier 3, and SUMO3 as the antigen and it reacts with Human.
Description
Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed: 11451954, PubMed: 18538659, PubMed: 21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed: 24105744)