MyBioSource.com's Anti-Ms CD11b APC is a Rat monoclonal antibody. The Anti-Ms CD11b APC Antibody was generated using integrin alpha M, and ITGAM as the antigen. It reacts with Human, Mouse, Non-Human Primate, and Rabbit. This antibody has been shown to work in applications such as: Flow Cytometry.
Description
CD11b (integrin alphaM subunit) is a 165-170 kDa type I transmembrane glycoprotein that non-covalently associates with integrin beta2 subunit (CD18); expression of the CD11b chain on the cell surface requires the presence of the CD18 antigen. CD11b/CD18 integrin (Mac-1, CR3) is highly expressed on NK cells, neutrophils, monocytes and less on macrophages. CD11b/CD18 integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes, facilitating their diapedesis, as well as it mediates the uptake of complement coated particles, serving as a receptor for the iC3b fragment of the third complement component