MyBioSource.com's Rabbit Anti-NMDA 2B Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The Rabbit Anti-NMDA 2B Antibody was generated using GRIN2B as the antigen and it reacts with Human, and Mouse.
Description
Component ofnMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+ (PubMed: 8768735, PubMed: 26919761, PubMed: 26875626, PubMed: 28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed: 8768735, PubMed: 26875626). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synapticnMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity