The Rabbit Anti-E2A Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to TCF3. This antibody recognizes Human, Mouse, and Rat antigen. The Rabbit Anti-E2A Antibody has been shown to work in the following applications: Other.
Description
E2A is a transcription factor that plays major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Heterodimers between E2A and tissue-specific basic helix-loop-helix (bHLH) Dimers bind DNA on E-box motifs: 5'- CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Deletions in E2A have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Two alternatively spliced human isoforms have been described