MyBioSource.com's Rabbit Anti-Interleukin-12 Subunit beta Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Other. The Rabbit Anti-Interleukin-12 Subunit beta Antibody was generated using IL12B, and Interleukin 12B as the antigen and it reacts with Human.
Description
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Ref.12Associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis