MyBioSource.com's Anti-Rt CD8a Purified Low Endotoxin is a Mouse monoclonal antibody. The Anti-Rt CD8a Purified Low Endotoxin Antibody was generated using CD8A as the antigen. It reacts with Rat. This antibody has been shown to work in applications such as: Cell Sorting, Isolation, Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, Immunohistochemistry - frozen, Immunoprecipitation, and Western Blot.
Description
The CD8a (CD8 alpha) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector Functional Application (FUNC)tion. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the Functional Application (FUNC)tional diversity of the TCR signaling