MyBioSource.com's Rabbit Anti-Caspase 9 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Flow Cytometry, and Immunofluorescence. The Rabbit Anti-Caspase 9 Antibody was generated using CASP9, and Caspase 9 as the antigen and it reacts with Human, Mouse, Rat, and Canine.
Description
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1 c-Abl-dependent manner. Proteolytically cleaves poly (ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9