The Rabbit Anti-GABA A alpha 5 Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to GABRA5, and gamma-aminobutyric acid type A receptor subunit alpha5. This antibody recognizes Human, Mouse, and Rat antigen. The Rabbit Anti-GABA A alpha 5 Antibody has been shown to work in the following applications: Other.
Description
GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA Ralpha1-6, GABAA R beta 1-3, GABAA Rgamma1-3, GABAA Rdelta, GABAA Repsilon, GABAA Rï1 and GABAA Rï2. The GABAB family is composed of GABAB R1alpha and GABAB R1beta. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action