The Rabbit Anti-DNAMethyltransferase3A Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to DNMT3A. This antibody recognizes Human antigen. The Rabbit Anti-DNAMethyltransferase3A Antibody has been shown to work in the following applications: Other.
Description
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity