The Rabbit Anti-CaSR Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to Casr. This antibody recognizes Human, Mouse, and Rat antigen. The Rabbit Anti-CaSR Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, Immunocytochemistry, Immunofluorescence, and Western Blot.
Description
calcium sensing receptor (CASR), Homo sapiens. The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq, Jul 2008]